The Race for Diagnosis of Polycystic Ovary Syndrome (2024)

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Geralyn Lambert-Messerlian

Department of Pathology and Laboratory Medicine, Women and Infants Hospital and the Alpert Medical School at Brown University

,

Providence, RI 02903

,

USA

Department of Obstetrics and Gynecology, Women and Infants Hospital and the Alpert Medical School at Brown University

,

Providence, RI 02903

,

USA

Correspondence: Geralyn Lambert-Messerlian, PhD, Women and Infants Hospital and the Alpert Medical School at Brown University, 70 Elm Street, 2nd floor, Providence, RI 02903, USA. Email: gmesserlian@wihri.org.

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Polycystic ovary syndrome (PCOS) is a recognized risk factor for the long-term health of women. PCOS is not only a challenge for reproductive health; it conveys lifelong risks for diabetes, dyslipidemia, hypertension, obstructive sleep apnea, endometrial cancer, and cardiovascular disease, among other morbidities (1). These increased risks persist even when controlling for high body mass index, a common feature of PCOS, and most apply across premenopausal and postmenopausal women. The health consequences are exacerbated by missed or late diagnoses, which are common. One provocative study showed that it often took more than 2 years and 3 different health care providers for women to receive a diagnosis of PCOS, regardless of residing in North America, Europe, or other parts of the world (2).

An ongoing challenge in diagnosing PCOS and understanding its prevalence has been the lack of uniformity in clinical criteria (3). The National Institutes of Health (NIH), in 1990, was first to introduce diagnostic criteria for PCOS. A Rotterdam expert consensus (2003) then expanded the definition and later, the Androgen Excess and PCOS Society (2006) proposed a modification. Currently, the NIH evidence-based workshop (2012) recommends diagnosis by 2 of 3 criteria: ovulatory dysfunction, biochemical or clinical hyperandrogenism, and/or polycystic ovary morphology. Patients are categorized into 1 of 4 PCOS phenotypes based on the clinical findings.

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    • Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study

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The Race for Diagnosis of Polycystic Ovary Syndrome (2024)

FAQs

What race is most affected by PCOS? ›

Hispanic women with PCOS have the most severe phenotype, both in terms of hyperandrogenism and metabolic criteria. Non-Hispanic Black women have an overall milder polycystic ovarian syndrome phenotype than Hispanics and in some respects, than Non-Hispanic White women.

What is the diagnosis of polycystic ovary syndrome? ›

Diagnosis criteria

you have irregular periods or infrequent periods – this indicates that your ovaries do not regularly release eggs (ovulate) blood tests showing you have high levels of "male hormones", such as testosterone (or sometimes just the signs of excess male hormones, even if the blood test is normal)

Who is more likely to get PCOS? ›

The cause of PCOS is unknown but women with a family history or type 2 diabetes are at higher risk.

What is polycystic ovary syndrome problem statement? ›

Key points about PCOS

PCOS can cause missed or irregular menstrual periods, excess hair growth, acne, infertility, and weight gain. Women with PCOS may be at higher risk for type 2 diabetes, high blood pressure, heart problems, and endometrial cancer.

Which country has the highest PCOS rate? ›

The age-standardised annual incidence rate of PCOS also varied substantially by country. In 2019, Kuwait [108.6 (95% UI: 71.7 to 151.4)], Qatar [105.1 (95% UI: 68.0 to 147.9)] and Saudi Arabia [103.0 (95% UI: 66.9 to 143.0)] had the highest age-standardised annual incidence rates.

Why do so many Indians have PCOS? ›

Ethnic Indian women present with altered genetic susceptibility leading to early onset and increased severity of symptoms in most complex diseases, including PCOS [17].

What does a PCOS belly look like? ›

It's usually large and bloated but can also be small and round, depending on genes and other factors. It involves visceral fat accumulation in the lower abdomen and typically feels hard to touch. A PCOS belly is also characterized by a high waist-to-hip ratio of >0.87 (apple body shape).

Are people with PCOS more likely to have a boy or girl? ›

Results: No significant difference in sex ratio was detected between PCOS and controls, even if it resulted significantly different in the full-blown and non-PCO phenotypes.

What is the life expectancy of a person with PCOS? ›

The group with PCOS had been diagnosed at a mean age of 27 years. The mean follow-up time was 13.1 years in both groups, during which 1,003 controls and 177 women with PCOS died. The mean age at death was 51.4 years for the PCOS group versus 52.6 years for the control women, a significant difference (P < . 001).

Do any celebrities have PCOS? ›

Emma Thompson. The legendary actress has proven that you can achieve great things (um, hello, she won an Oscar) while living with PCOS and clinical depression. After struggling with infertility, Emma underwent in vitro fertilization (IVF) to help her conceive her daughter, Gaia.

At what age is PCOS most common? ›

Experts estimate that 5 to 10 percent of women ages 18 to 44 have PCOS. The syndrome is usually detected in women between ages 20 and 30, but the earliest signs can be evident in younger girls including those who have not yet started menstruation.

What is the best age to have a baby with PCOS? ›

While there's no one-size-fits-all answer, experts generally recommend that individuals with PCOS start trying to conceive sooner rather than later. The late twenties and early thirties are considered the best age to get pregnant with PCOS.

Can PCOS go away? ›

Polycystic ovary syndrome (PCOS) cannot be cured, but the symptoms can be managed. Treatment options can vary because someone with PCOS may experience a range of symptoms, or just 1. The main treatment options are discussed in more detail below.

What is the root cause of PCOS? ›

The exact cause of PCOS is unknown. There's evidence that genetics play a role. Several other factors, most importantly obesity, also play a role in causing PCOS: Higher levels of male hormones called androgens: High androgen levels prevent your ovaries from releasing eggs, which causes irregular menstrual cycles.

Is PCOS a lifelong disease? ›

PCOS can cause irregular menstruation (periods), and is a common cause of infertility, affecting as many as 5 million people. In addition to infertility, it is a lifelong condition that can have other impacts.

What populations are affected by PCOS? ›

PCOS affects 7–10% of women of childbearing age and is the most common cause of infertility. In the United States, an estimated 5 to 6 million women have PCOS. PCOS is the most common hormonal disorder among women of reproductive age, but many women don't know they have it.

What are PCOS prone to? ›

Women with polycystic ovary syndrome (PCOS) are at higher risk for several other health conditions, some of them serious.
  • Insulin Resistance. ...
  • Metabolic Syndrome. ...
  • Type 2 Diabetes. ...
  • Obesity. ...
  • Heart Disease and High Blood Pressure (Cardiovascular Disease) ...
  • Obstructive Sleep Apnea. ...
  • Mood Disorders. ...
  • Inflammation.
Sep 29, 2022

What side of the family does PCOS come from? ›

If you have a mother or sister with PCOS or a first-degree relative with diabetes or glucose intolerance, this may mean you're more likely to develop the condition. An estimated one-quarter of people with PCOS have mothers with the condition, and one-third have sisters with the condition.

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